![]() ![]() She is also boarder line diabetic and takes Metformin. It is ALSO HEREDITARY! I have a 13yr old daughter, who has had medical problems since birth. Quit body shaming others that isn’t skinny. Mental health is also important, and eating potato chips while binging shows on my couch makes me happy, so leave me alone!!! “Healthy” is probably a made up word without any scientific basis. Enough already with medical professionals and society trying to get us healthy, it’s obviously not going to work, we’re also genetically predisposed to resisting critiques, even if it can make us healthier. Now that we are informed, we know it’s not our fault and we can choose our own unhealthy lifestyles. The authors declare no competing interests.ĭan has a point, all you bigots out their need to get off your high horses and stop shaming people for their bad health practices like smoking, heavy drinking, and eating too many calories.Īlso some percent, maybe 40%, might be a disposition towards obesity, which means people can’t help it that they eat too much pizza and don’t exercise, and if they can’t help it, why try? True, obesity rates have increased 27-47% worldwide over the past 30 years, and while our genetics don’t mutate that quickly, those people 30+ years ago who were genetically predisposed just didn’t realize it. Research reported in this publication was supported by NIDDK at the National Institutes of Health, the UCLA Life Sciences Fund, and UCLA Graduate Council Diversity Fellowship. Reference: “Adipose tissue plasticity in health and disease” by Alexander Sakers, Mirian Krystel De Siqueira, Patrick Seale and Claudio J. “Many questions and opportunities for future discovery remain, which will yield new insights into adipose tissue biology and hopefully lead to improved therapies for human disease.” Villanueva from the College of Life Sciences/David Geffen School of Medicine and Patrick Seale from Perelman School of Medicine at the University of Pennsylvania. “The central role of adipose tissue dysfunction in disease and the incredible plasticity of fat tissue supports the promise of modulating fat tissue phenotypes for therapeutic purposes,” write the authors, led by Claudio J. The hallmarks of adipose tissue dysfunction. This leads to insulin resistance, inflammation, and cell death accompanied by the uncontrolled spill of lipids from these cells. In the current model of this phenomenon, the rapid growth of adipose tissue outpaces its blood supply, depriving the fat cells of oxygen and causing the accumulation of cells that no longer divide. As fat declines in plasticity due to aging and obesity, it loses its ability to respond to bodily cues. The makeup and functioning of this tissue changes in response to weight fluctuations and aging. In a review published in the journal Cell on February 3rd, 2022, researchers argue that the negative health effects of obesity stem not simply from an excess of fat but from the decline in its ability to respond to changes, or in other words, its plasticity. On a basic level, fat acts as a receptacle to store energy, but upon a closer look it is an essential actor in vital bodily processes like the immune response, the regulation of insulin sensitivity, and maintenance of body temperature. Obesity is known to cause cardiometabolic diseases like hypertension and diabetes but attributing these diseases to merely an overabundance of fat is a simplification. The researchers highlight the potential of altering fat tissue phenotypes for therapeutic benefits, pointing to an exciting avenue for future medical advancements. This decline leads to health issues such as insulin resistance and inflammation. As fat loses its plasticity due to aging and obesity, it can’t respond to bodily cues, leading to insulin resistance, inflammation, and cell death due to the fast growth of adipose tissue that outstrips its blood supply.Ī review in the Cell journal reveals that the negative health impacts of obesity are not merely due to excess fat, but rather a loss of fat’s plasticity, its ability to respond to changes. The researchers explain that fat, besides storing energy, plays crucial roles in immune response, insulin sensitivity regulation, and body temperature maintenance. ![]() Obesity’s detrimental health effects, such as hypertension and diabetes, stem not merely from an excess of fat, but rather from the loss of fat’s plasticity - its ability to respond to changes - according to a review published in the Cell journal. ![]()
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